MIT chemical engineers have developed a new treatment for an aggressive form of breast cancer whose tumors resist chemotherapy drugs. Led by David H. Koch Professor in Engineering Paula Hammond, the team designed nanoparticles that pack a one-two punch: They deliver a cancer drug along with short strands of RNA that shut off genes used by cancer cells to escape the drug. The nanoparticles are also coated with an outer layer that protects them from degrading while en route to the cancer cells. The researchers used the particles to successfully shrink breast tumors in mice, as they report in a recent issue of the journal ACS Nano. The lead author on the paper is Jason Deng, a postdoc in Hammond’s lab.
Explore Professor Hammond’s research in the Open Access Articles collection in DSpace@MIT, where it is openly accessible to the world.
Since the MIT faculty established their Open Access Policy in March 2009 they have made thousands of research papers freely available to the world via DSpace@MIT. To highlight that research, we’re offering a series of blog posts that link news stories about scholars’ work to their open access papers in DSpace.